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KMID : 0380620180500040420
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Korean Journal of Food Science and Technology
2018 Volume.50 No. 4 p.420 ~ p.429
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Cutaneous hydration effect of collagen hydrolysate containing collagen tripeptides
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Kim Ae-Hyang
Kim Yi-Soo
Piao Zhe
Shin Yong-Chul
Ha Min-Woo
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Abstract
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Skin ageing is associated with compromised performance of its fundamental barrier functions, with undesirable changes in appearance. Since this may introduce a detrimental impact on the quality of life, significant effort to discover effective ingredients against ageing is being invested. Recently, collagen hydrolysates containing tripeptides such as Gly-Pro-Hyp (GPH) have been developed with anticipation of improved effects compared to that of existing collagen hydrolysate-products. To evaluate the cutaneous hydration effect of collagen tripeptides (CTP), meaningful biomarkers in human dermal fibroblasts (HDF) and NC/Nga Tnd mice were analyzed in this study. Increased levels of ceramide kinase, hyaluronic acid, collagen 1A, and hyaluronan synthase-2 (HAS2), and decreased levels of hyaluronidase-1 (HYAL1) and CD44 in HDF cells were demonstrated. Furthermore, significant reduction of transepidermal water loss (TEWL), scratching behavior, HYAL1, TNF-α and IL-6 and increased water content and HAS2 were verified by in vivo tests. These results strongly suggest the potential of CTP as a skin hydration agent.
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KEYWORD
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collagen tripeptide, collagen hydrolysate, hydration effect, skin ageing, glycine-proline-hydroxyproline
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